Exposure of trophoblast cells to fine particulate matter air pollution leads to growth inhibition, inflammation and ER stress
Mary Familari, Asa Naav, Lena Erlandsson, Robb U de Iongh, Christina Isaxon, Bo Strandberg, Thomas Lundh, Stefan R Hansson, Ebba Malmqvist
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2019
Ambient air pollution is considered a major environmental health threat to pregnant women. Our previous work has shown an association between exposure to airborne particulate matter (PM) and an increased risk of developing pre-eclamspia. It is now recognized that many pregnancy complications are due to underlying placental dysfunction, and this tissue plays a pivotal role in pre-eclamspia. Recent studies have shown that PM can enter the circulation and reach the human placenta but the effects of PM on human placental function are still largely unknown. In this work we investigated the effects of airborne PM on trophoblast cells. Human, first trimester trophoblast cells (HTR-8/SV) were expose..View full abstract
Awarded by Swedish Research Council Forte Funding (Stiftelsen for Miljostrategisk Forskning)
This work was supported by the FP7 Ideas: European Research Council ReproUnion (http://reprounion.eu/) and Swedish Research Council Forte Funding (Stiftelsen for Miljostrategisk Forskning) 2016-00572 (https://forte.se/en/) to MF, CI, SRH & EM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.