MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer
Oussama ElMokh, Vincent Taelman, Piotr Radojewski, Matthias A Roelli, Amandine Stoss, Rebecca A Dumont, Matthias S Dettmer, Wayne A Phillips, Martin A Walter, Roch-Philippe Charles
JOURNAL OF NUCLEAR MEDICINE | SOC NUCLEAR MEDICINE INC | Published : 2019
Anaplastic thyroid carcinoma (ATC) is refractory to radioiodine therapy in part because of impaired iodine metabolism. We targeted the mitogen-activated protein kinase and phosphatidylinositol 3-kinase (PI3'K) pathways with the intent to induce radioiodine uptake for radioiodine treatment of ATC. Methods: Human ATC cells were used to evaluate the ability of pharmacologic inhibition of the mitogen-activated protein kinase and PI3'K pathways to induce radioiodine uptake. Thyrocyte-specific double-mutant BRAFV600E PIK3CAH1047R mice were treated with a MEK inhibitor followed by radioiodine treatment, and tumor burden was monitored by ultrasound imaging. Results: ATC cell lines showed an increase..View full abstract
Awarded by Swiss National Science Foundation
Funding support was provided by Swiss National Science Foundation grant 31003A_149824/1 and Swiss National Science Foundation grant NCCR-TransCure. No other potential conflict of interest relevant to this article was reported.