Quantifying individual differences in brain morphometry underlying symptom severity in Autism Spectrum Disorders
Emmanuel Peng Kiat Pua, Gareth Ball, Chris Adamson, Stephen Bowden, Marc L Seal
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2019
The neurobiology of heterogeneous neurodevelopmental disorders such as autism spectrum disorders (ASD) are still unclear. Despite extensive efforts, most findings are difficult to reproduce due to high levels of individual variance in phenotypic expression. To quantify individual differences in brain morphometry in ASD, we implemented a novel subject-level, distance-based method on subject-specific attributes. In a large multi-cohort sample, each subject with ASD (n = 100; n = 84 males; mean age: 11.43 years; mean IQ: 110.58) was strictly matched to a control participant (n = 100; n = 84 males; mean age: 11.43 years; mean IQ: 110.70). Intrapair Euclidean distance of MRI brain morphometry and..View full abstract
Awarded by Royal Children's Hospital Foundation
Data analysis and interpretation was conducted within the Developmental Imaging research group, Murdoch Children's Research Institute and the Children's MRI Centre, Royal Children's Hospital, Melbourne, Victoria. The research was supported by the Murdoch Children's Research Institute, The Royal Children's Hospital, Department of Paediatrics, The University of Melbourne and the Victorian Government's Operational Infrastructure Support Program. The project was generously supported by RCH1000, a unique arm of The Royal Children's Hospital Foundation devoted to raising funds for research at The Royal Children's Hospital.