Journal article

Has the sun set for seasonal affective disorder and HPA axis studies? A systematic review and future prospects

Bruno Agustini, Mariia Bocharova, Adam J Walker, Michael Berk, Allan H Young, Mario F Juruena



OBJECTIVE: Seasonal Affective Disorder (SAD) is a form of cyclic mood disorder that tends to manifest as winter depression. SAD has anecdotally been described as a hypocortisolemic condition. However, there are no systematic reviews on SAD and Hypothalamic-Pituitary-Adrenal (HPA) axis function. This review intends to summarize these findings. METHODS: Using the PRISMA (2009) guideline recommendations we searched for relevant articles indexed in databases including MEDLINE, EMBASE, PsycINFO, and PsychArticles. The following keywords were used: "Seasonal affective disorder", OR "Winter Depression", OR "Seasonal depression" associated with: "HPA Axis" OR "cortisol" OR "CRH" OR "ACTH". RESULTS: ..

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University of Melbourne Researchers


Awarded by NHMRC

Funding Acknowledgements

MB is supported by a NHMRC Senior Principal Research Fellowship (APP1059660 and APP1156072). MF Juruena was supported by Academy of Medical Sciences/Royal Society. It also represents independent research part funded MF Juruena by the NIHR and Biomedical Research Centre at South London and Maudsely NHS Foundation Trust and King's College London. AJW is supported by a Trisno Family Fellowship.