Cognitive Implications of Ototoxicity in Pediatric Patients With Embryonal Brain Tumors
Traci W Olivier, Johnnie K Bass, Jason M Ashford, Rebecca Beaulieu, Sarah M Scott, Jane E Schreiber, Shawna Palmer, Donald J Mabbott, Michelle A Swain, Melanie Bonner, Robyn Boyle, Mary Lynn Chapeiski, Karen D Evankovich, Carol L Armstrong, Sarah J Knight, Shengjie Wu, Arzu Onar-Thomas, Amar Gajjar, Heather M Conklin
Journal of Clinical Oncology | AMER SOC CLINICAL ONCOLOGY | Published : 2019
PURPOSE: Sensorineural hearing loss (SNHL) is associated with intellectual and academic declines in children treated for embryonal brain tumors. This study expands upon existing research by examining core neurocognitive processes that may result in reading difficulties in children with treatment-related ototoxicity. PATIENTS AND METHODS: Prospectively gathered, serial, neuropsychological and audiology data for 260 children and young adults age 3 to 21 years (mean, 9.15 years) enrolled in a multisite research and treatment protocol, which included surgery, risk-adapted craniospinal irradiation (average risk, n = 186; high risk, n = 74), and chemotherapy, were analyzed using linear mixed model..View full abstract
Awarded by National Cancer Institute (St Jude Cancer Center Support [Core] Grant)
Awarded by NATIONAL CANCER INSTITUTE
Supported in part by the National Cancer Institute (St Jude Cancer Center Support [Core] Grant No. P30 CA21765) and the American Lebanese Syrian Associated Charities.