Journal article

Cognitive Implications of Ototoxicity in Pediatric Patients With Embryonal Brain Tumors

Traci W Olivier, Johnnie K Bass, Jason M Ashford, Rebecca Beaulieu, Sarah M Scott, Jane E Schreiber, Shawna Palmer, Donald J Mabbott, Michelle A Swain, Melanie Bonner, Robyn Boyle, Mary Lynn Chapeiski, Karen D Evankovich, Carol L Armstrong, Sarah J Knight, Shengjie Wu, Arzu Onar-Thomas, Amar Gajjar, Heather M Conklin

Journal of Clinical Oncology | AMER SOC CLINICAL ONCOLOGY | Published : 2019

Abstract

PURPOSE: Sensorineural hearing loss (SNHL) is associated with intellectual and academic declines in children treated for embryonal brain tumors. This study expands upon existing research by examining core neurocognitive processes that may result in reading difficulties in children with treatment-related ototoxicity. PATIENTS AND METHODS: Prospectively gathered, serial, neuropsychological and audiology data for 260 children and young adults age 3 to 21 years (mean, 9.15 years) enrolled in a multisite research and treatment protocol, which included surgery, risk-adapted craniospinal irradiation (average risk, n = 186; high risk, n = 74), and chemotherapy, were analyzed using linear mixed model..

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Grants

Awarded by National Cancer Institute (St Jude Cancer Center Support [Core] Grant)


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

Supported in part by the National Cancer Institute (St Jude Cancer Center Support [Core] Grant No. P30 CA21765) and the American Lebanese Syrian Associated Charities.