Journal article
Adjunctive minocycline for major mental disorders: A systematic review
W Zheng, XM Zhu, QE Zhang, G Cheng, DB Cai, J He, CH Ng, GS Ungvari, XJ Peng, YP Ning, YT Xiang
Journal of Psychopharmacology | SAGE PUBLICATIONS LTD | Published : 2019
Abstract
Objectives: This meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of minocycline for three major mental disorders: schizophrenia, bipolar disorder and major depressive disorder (MDD). Methods: A systematic literature search of major electronic databases was conducted. Meta-analysis of clinical efficacy as defined by the respective studies, all-cause discontinuation, adverse drug reactions (ADRs) with standardized mean difference (SMD) and risk ratios (RRs) and their 95% confidence intervals (CI) was conducted using random-effects model. Quality assessment was performed with the Jadad scale and Cochrane risk of bias. Results: Sixteen RCTs (n=1357) on minoc..
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Awarded by Guangzhou Science and Technology Program key projects
Funding Acknowledgements
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was supported by the National Key Research and Development Plan "Precision Medical Research" 2016 Project (2016YFC0906302), the Science and Technology Program of Guangzhou (201807010064), and the Natural Science Foundation of Jiangsu Province (Grants No BK20180213).