Journal article
Antibiotic Class and Outcome in Post-stroke Infections: An individual participant data pooled analysis of VISTA-acute
CJ Smith, C Heal, A Vail, AR Jeans, WF Westendorp, PJ Nederkoorn, D Van De Beek, L Kalra, J Montaner, M Woodhead, A Meisel, KR Lees, A Alexandrov, PM Bath, E Berge, E Bluhmki, N Bornstein, C Chen, L Claesson, SM Davis Show all
Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2019
Abstract
Introduction: Antibiotics used to treat post-stroke infections have differing antimicrobial and anti-inflammatory effects. Our aim was to investigate whether antibiotic class was associated with outcome after post-stroke infection. Methods: We analyzed pooled individual participant data from the Virtual International Stroke Trials Archive (VISTA)-Acute. Patients with ischemic stroke and with an infection treated with systemic antibiotic therapy during the first 2 weeks after stroke onset were eligible. Antibiotics were grouped into eight classes, according to antimicrobial mechanism and prevalence. The primary analysis investigated whether antibiotic class for any infection, or for pneumonia..
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Funding Acknowledgements
The Open Access Publication Fund of Charite-Universitatsmedizin Berlin and Professor Meisel as corresponding author will provide funding to cover the open access publication/article processing fee.