Journal article
AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis
OJ Katwan, F Alghamdi, TA Almabrouk, SJ Mancini, S Kennedy, JS Oakhill, JW Scott, IP Salt
Biochemical Journal | PORTLAND PRESS LTD | Published : 2019
DOI: 10.1042/BCJ20180714
Open access
Abstract
AMP-activated protein kinase (AMPK) is a heterotrimer of α-catalytic and β- and γ-regula-tory subunits that acts to regulate cellular and whole-body nutrient metabolism. The key role of AMPK in sensing energy status has led to significant interest in AMPK as a therapeutic target for dysfunctional metabolism in type 2 diabetes, insulin resistance and obesity. Despite the actions of AMPK in the liver and skeletal muscle being extensively studied, the role of AMPK in adipose tissue and adipocytes remains less well characterised. Small molecules that selectively influence AMPK heterotrimers containing specific AMPKβ subunit isoforms have been developed, including MT47-100, which selectively inhi..
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Awarded by Ministry of Education, Libya
Funding Acknowledgements
This work was supported by a Project Grant [PG/13/82/30483 to I.P.S.] from the British Heart Foundation and an Equipment Grant [BDA11/0004309 to I.P.S.] from Diabetes UK. O.J.K. was supported by a Scholarship from the Iraqi Ministry of Higher Education and Scientific Research. F.A. was supported by a Scholarship from King Abdulaziz University. T.A.A. was supported by a Libyan Ministry of Education PhD Studentship. J.W.S. and J.S.O. are supported by Project Grants [GNT1138102 and GNT1098459, respectively] from the National Health and Medical Research Council, Australia.