Genomics for Molecular Epidemiology and Detecting Transmission of Carbapenemase-Producing Enterobacterales in Victoria, Australia, 2012 to 2016
Norelle L Sherry, Courtney R Lane, Jason C Kwong, Mark Schultz, Michelle Sait, Kerrie Stevens, Susan Ballard, Anders Goncalves da Silva, Torsten Seemann, Claire L Gorrie, Timothy P Stinear, Deborah A Williamson, Judith Brett, Annaliese van Diemen, Marion Easton, Benjamin P Howden
JOURNAL OF CLINICAL MICROBIOLOGY | AMER SOC MICROBIOLOGY | Published : 2019
Carbapenemase-producing Enterobacterales (CPE) are being increasingly reported in Australia, and integrated clinical and genomic surveillance is critical to effectively manage this threat. We sought to systematically characterize CPE in Victoria, Australia, from 2012 to 2016. Suspected CPE were referred to the state public health laboratory in Victoria, Australia, from 2012 to 2016 and examined using phenotypic, multiplex PCR and whole-genome sequencing (WGS) methods and compared with epidemiological metadata. Carbapenemase genes were detected in 361 isolates from 291 patients (30.8% of suspected CPE isolates), mostly from urine (42.1%) or screening samples (34.8%). IMP-4 (28.0% of patients)..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
This work is supported by the National Health and Medical Research Council (NHMRC) through a partnership grant (GNT1149991), individual supporting grants (GNT1142613 to J.C.K., GNT1008549 to T.P.S., GNT1123854 to D.A.W., and GNT1105905 to B.P.H.), and a research grant (to N.L.S. and J.C.K.) from the Australian Society for Antimicrobials. N.L.S. and C.R.L. are supported by Australian Government Research Training Program (RTP) scholarships.