Journal article

Blood-based biomarkers in the maternal circulation associated with fetal growth restriction

Stephen Tong, Tu'uhevaha Joy Kaitu'u-Lino, Susan Philippa Walker, Teresa Mary MacDonald

PRENATAL DIAGNOSIS | WILEY | Published : 2019

Abstract

Fetal growth restriction (FGR) is associated with threefold to fourfold increased risk of stillbirth. Identifying FGR, through its commonly used surrogate-the small-for-gestational-age (SGA, estimated fetal weight and/or abdominal circumference <10th centile) fetus-and instituting fetal surveillance and timely delivery decrease stillbirth risk. Methods available to clinicians for antenatal identification of SGA fetuses have surprisingly poor sensitivity. About 80% of cases remain undetected. Measuring the symphysis-fundal height detects only 20% of SGA fetuses, and even universal third trimester ultrasound detects, at best, 57% of those born SGA. There is an urgent need to find better ways t..

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