Journal article

The association between pneumococcal vaccination, ethnicity, and the nasopharyngeal microbiota of children in Fiji

Laura K Boelsen, Eileen M Dunne, Moana Mika, Stefanie Eggers, Cattram D Nguyen, F Tupou Ratu, Fiona M Russell, E Kim Mulholland, Markus Hilty, Catherine Satzke

Microbiome | BMC | Published : 2019

Abstract

BACKGROUND: Streptococcus pneumoniae is a significant global pathogen that colonises the nasopharynx of healthy children. Pneumococcal conjugate vaccines, which reduce nasopharyngeal colonisation of vaccine-type S. pneumoniae, may have broader effects on the nasopharyngeal microbiota; however, data are limited. In Fiji, nasopharyngeal carriage prevalence of S. pneumoniae and other colonising species differ between the two main ethnic groups. Here, we examined the association between the 7-valent pneumococcal conjugate vaccine (PCV7) and the nasopharyngeal microbiota of children in Fiji, including for each of the two main ethnic groups-indigenous Fijians (iTaukei) and Fijians of Indian descen..

View full abstract

Grants

Funding Acknowledgements

LB was supported by a Fay Marles Scholarship, The University of Melbourne. CS was supported by an Australian NHMRC Career Development Fellowship and a veski Inspiring Women Fellowship. The Murdoch Children's Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program. Funders had no role in study design, collection, analysis, and interpretation of data, or manuscript preparation.