Neuroanatomical alterations in people with high and low cannabis dependence
Valentina Lorenzetti, Yann Chye, Chao Suo, Mark Walterfang, Dan Lubman, Michael Takagi, Sarah Whittle, Antonio Verdejo-Garcia, Janna Cousijn, Christos Pantelis, Marc Seal, Alex Fornito, Murat Yucel, Nadia Solowij
Australian & New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2019
OBJECTIVES: We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regions of the stress and reward brain circuits. METHODS: To examine dependence-specific regional brain alterations, we compared the volumes of regions relevant to reward and stress, between high-dependence cannabis users (CD+, n = 25), low-dependence cannabis users (CD-, n = 20) and controls (n = 37). RESULTS: Compared to CD- and/or controls, the CD+ group had lower cerebellar white matter and hippocampal volumes, and deflation of the right hippocampus head and tail. CONCLUSION: These findings provide initial support for neuroadaptations involving stress and reward ci..View full abstract
Awarded by NHMRC
Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship L2
Awarded by NHMRC Senior Principal Research Fellowship
The author(s) received the following financial support for the research, authorship and/or publication of this article: This study was supported by a NHMRC Project Grant (#459111). Yann Chye was supported by a Monash Postdoctoral Bridging Fellowship. Sarah Whittle was supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship L2 (APP1125504). Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship (1105825). Alex Fornito was supported by the Sylvia and Charles Viertel Foundation.