Journal article

Functional correlates of cognitive dysfunction in clinically isolated syndromes

Sanuji Gajamange, Annie Shelton, Meaghan Clough, Owen White, Joanne Fielding, Scott Kolbe

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2019

Abstract

Cognitive dysfunction can be identified in patients with clinically isolated syndromes suggestive of multiple sclerosis using ocular motor testing. This study aimed to identify the functional neural correlates of cognitive dysfunction in patients with clinically isolated syndrome using MRI. Eighteen patients with clinically isolated syndrome and 17 healthy controls were recruited. Subjects underwent standard neurological and neuropsychological testing. Subjects also underwent functional MRI (fMRI) during a cognitive ocular motor task, involving pro-saccade (direct gaze towards target) and anti-saccade (direct gaze away from target) trials. Ocular motor performance variables (averaged respons..

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Grants

Awarded by Multiple Sclerosis Research Australia


Funding Acknowledgements

This work was supported by the Multiple Sclerosis Research Australia (postgraduate scholarship #14-088, SG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This work was supported by the Multiple Sclerosis Research Australia (Postgraduate Scholarship #14-088, SG). Remaining authors report no disclosures or conflicts of interest related to this manuscript.