Biomechanical Leg Muscle Function during Stair Ambulation in Men Receiving Androgen Deprivation Therapy

AS Cheung; HA Gray; AG Schache; R Hoermann; J Bicknell; DL Joon; JD Zajac; MG Pandy; M Grossmann; A Newman

Journal article

Biomechanical Leg Muscle Function during Stair Ambulation in Men Receiving Androgen Deprivation Therapy

AS Cheung, HA Gray, AG Schache, R Hoermann, J Bicknell, DL Joon, JD Zajac, MG Pandy, M Grossmann, A Newman

Journals of Gerontology Series A Biological Sciences and Medical Sciences | OXFORD UNIV PRESS INC | Published : 2020

DOI: 10.1093/gerona/glz169

Abstract

Background: The role of testosterone in maintaining functional performance in older men remains uncertain. Methods: We conducted a 12-month prospective, observational case-control study including 34 men newly commencing androgen deprivation therapy for prostate cancer and 29 age-matched prostate cancer controls. Video-based motion capture and ground reaction force data combined with computational musculoskeletal modeling, and data were analyzed with a linear mixed model. Results: Compared with controls over 12 months, men receiving androgen deprivation therapy had a mean reduction in circulating testosterone from 14.1 nmol/L to 0.4 nmol/L, associated with reductions in peak knee extension to..

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

This study was supported by an National Health and Medical Research Council of Australia (NHMRC) project grant (#1006407). A.S.C. is supported by a NHMRC postgraduate scholarship (#1017233), NHMRC early career fellowship (#1143333), Viertel Charitable Foundation Clinical Investigator Award and RACP Vincent Fairfax Family Foundation Fellowship. M.G. is supported by a NHMRC Career Development Fellowship (#1024139). Support provided by an Australian Research Council Discovery Projects grant (DP1095366) and an Innovation Fellowship provided by the Victorian Endowment for Science, Knowledge, and Innovation to M.G.P. are also gratefully acknowledged.