Journal article

Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)

Joyce Y Huang, Tricia L Larose, Hung N Luu, Renwei Wang, Anouar Fanidi, Karine Alcala, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Neil E Caporaso, Mark P Purdue, Regina G Ziegler, Neal D Freedman, Qing Lan, Ross L Prentice, Mary Pettinger, Cynthia A Thomson, Qiuyin Cai, Jie Wu, William J Blot Show all



Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case-control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium. All biomarkers were quantified by mass spectrometry-based methods in serum/plasma samples collected on average 6 years before lung cancer diagnosis. Odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer associated with individual biomarkers wer..

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Awarded by National Cancer Institute

Awarded by National Institutes of Health

Awarded by U.S. Department of Health and Human Services

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

Grant sponsor: National Cancer Institute; Grant numbers: P01CA87969, P30CA016087, R01CA092447, R01CA144034, U01CA155340, U01CA202979, UM1CA167552, UM1CA173640, UM1CA182876, UM1CA182910, UM1CA182934, UM1CA186107; Grant sponsor: National Institutes of Health; Grant numbers: CA047988, CA097193, CA182913, CA34944, CA40360, HL043851, HL080467, HL099355, HL26490, HL34595, P30ES000260; Grant sponsor: U.S. Department of Health and Human Services; Grant numbers: HHSN261201500005C, HHSN268201100046C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C, HHSN271201600004C; Grant sponsor: VicHealth and Cancer Council Victoria and Australian National Health and Medical Research Council; Grant numbers: 1074383, 209057, 396414