Journal article

A population of nonneuronal GFR alpha 3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells

Jenny Thai, Alanna C Green, Lincon A Stamp, Nick J Spencer, Louise E Purton, Jason Ivanusic

Cell and Tissue Research | SPRINGER | Published : 2019


Artemin is a neurotrophic factor that plays a crucial role in the regulation of neural development and regeneration and has also been implicated in the pathogenesis of inflammatory pain. The receptor for artemin, GFRα3, is expressed by sympathetic and nociceptive sensory neurons, including some that innervate the bone marrow, but it is unclear if it is also expressed in other cell types in the bone marrow. Our goal in the present study was to characterise the expression of GFRα3 in nonneuronal cells in the bone marrow. Immunohistochemical studies revealed that GFRα3-expressing cells in the bone marrow are spatially associated with blood vessels and are in intimate contact with nerve fibres. ..

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