Relating excitatory and inhibitory neurochemicals to visual perception: A magnetic resonance study of occipital cortex between migraine events

YM Chan; K Pitchaimuthu; QZ Wu; OL Carter; GF Egan; DR Badcock; AM McKendrick

Journal article

Relating excitatory and inhibitory neurochemicals to visual perception: A magnetic resonance study of occipital cortex between migraine events

YM Chan, K Pitchaimuthu, QZ Wu, OL Carter, GF Egan, DR Badcock, AM McKendrick

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2019

DOI: 10.1371/journal.pone.0208666

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Abstract

Certain perceptual measures have been proposed as indirect assays of brain neurochemical status in people with migraine. One such measure is binocular rivalry, however, previous studies have not measured rivalry characteristics and brain neurochemistry together in people with migraine. This study compared spectroscopy-measured levels of GABA and Glx (glutamine and glutamate complex) in visual cortex between 16 people with migraine and 16 non-headache controls, and assessed whether the concentration of these neurochemicals explains, at least partially, inter-individual variability in binocular rivalry perceptual measures. Mean Glx level was significantly reduced in migraineurs relative to con..

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University of Melbourne Researchers

Olivia Carter Author

Allison McKendrick Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

[ "This work was supported by the National Health and Medical Research Council (NHMRC) Project Grant (APP1081874) (AMM). Author QW is an employee of Shenzhen Sinorad Medical Electronics Inc., Shenzhen, China. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.", "This work was supported by the National Health and Medical Research Council (NHMRC) Project Grant (GNT1081874)." ]