Journal article

Deciphering the role of epigenetics in self-limited epilepsy with centrotemporal spikes

Namitha Mohandas, Yuk Jing Loke, Lisa Mackenzie, Carmen Bennett, Samuel F Berkovic, Jeffrey M Craig, Lata Vadlamudi

Epilepsy Research | ELSEVIER | Published : 2019

Abstract

OBJECTIVE: The aetiology of self-limited epilepsy with centro-temporal spikes (SECTS) remains controversial and a strong genetic basis has long been presumed. The discordant monozygotic twin (MZ) model controls for shared genetic and environmental factors, enabling focus on the potential role of the non-shared environment. METHODS: DNA methylation data was acquired from DNA extracted from three discordant MZ twin pairs, from both new born blood spots before epilepsy onset, and blood samples taken after epilepsy onset. An epigenome-wide analysis was performed, using the Illumina Infinium EPIC array. Differentially methylated regions (DMR) were identified using the bumphunter package in R. Com..

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Grants

Awarded by Financial Markets Foundation for Children


Funding Acknowledgements

This work was supported by grant from the Financial Markets Foundation for Children (grant number 2013-207). LV was supported by a Queensland Health Research Fellowship. This work was also supported by The University of Queensland Mayne Bequest Funds, Royal Brisbane and Women's Foundation Grant, Viertal-Charitable Foundation, Ramaciotti Establishment Grant and The Servier Barry Young Fellowship in Neurology.