A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4
Paul R Gilson, Rasika Kumarasingha, Jennifer Thompson, Xinxin Zhang, Jocelyn Sietsma Penington, Robabeh Kalhor, Hayley E Bullen, Adele M Lehane, Madeline G Dans, Tania F de Koning-Ward, Jessica K Holien, Tatiana P Soares da Costa, Mark D Hulett, Melissa J Buskes, Brendan S Crabb, Kiaran Kirk, Anthony T Papenfuss, Alan F Cowman, Belinda M Abbott
Scientific Reports | NATURE PUBLISHING GROUP | Published : 2019
Awarded by Australian Research Council
Awarded by NHMRC
Awarded by National Health and Medical Research Council of Australia
We thank the Melbourne and Canberra branches of the Australian Red Cross Blood Bank for the provision of human blood. We are grateful to Stephen Wilcox for the Next Generation sequencing, conducted at the Ian Potter Centre for Genomics within the Walter and Eliza Hall Institute for Medical Research, Victoria Australia. M.G.D. is the recipient of an Australian Government Research Training Program (RTP) Scholarship. A.M.L. is supported by an Australian Research Council Discovery Early Career Researcher Award (DE160101035). T.P.S.C. is supported by NHMRC fellowship funding 1091976. The authors gratefully acknowledge funding from the Victorian Operational Infrastructure Support Program received by the Burnet Institute and for grants from the National Health and Medical Research Council of Australia (1068287, 1021560, 637406 and 1042272) and the Australian Research Council (LP150101226).