Stroke Laterality Did Not Modify Outcomes in the HERMES Meta-Analysis of Individual Patient Data of 7 Trials
Mohammed A Almekhlafi, Michael D Hill, Yvo M Roos, Bruce C Campbell, Keith W Muir, Andrew M Demchuk, Serge Bracard, Meritxell Gomis, Francis Guillemin, Tudor G Jovin, Bijoy K Menon, Peter Mitchell, Philip White, Aad van Der Lugt, Jeffrey Saver, Scott Brown, Mayank Goyal
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Background and Purpose- There is contradictory evidence on the impact of the stroke side (hemisphere) on outcomes. We investigated any effect modification by laterality on stroke patients' outcomes in recent endovascular trials. Methods- Individual patient-level data were combined in this meta-analysis of all patients included in randomized trials comparing endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischemic patients with stroke (HERMES [Highly Effective Reperfusion Using Multiple Endovascular Devices] Collaboration). We stratified the 90-day functional outcome assessed by ordinal analysis of the modified Rankin Scale accordi..View full abstract
The University of Calgary received an unrestricted grant from Medtronic for the HERMES (Highly Effective Reperfusion Using Multiple Endovascular Devices) collaboration initiative. The company had no role in the: design of the studies, data collection, data analysis or interpretation, drafting the reports, or the decision to submit the reports for publication. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.