Journal article

The Neurodevelopmental Outcomes of Patients With Single Ventricles Across the Lifespan

Karin du Plessis, Yves d'Udekem

The Annals of Thoracic Surgery | ELSEVIER SCIENCE INC | Published : 2019


BACKGROUND: Moderate to severe neurodevelopmental impairments are recognized as a significant comorbidity in one-fourth to one-third of single-ventricle patients. This report reviews the nature of neurodevelopment across the lifespan, contributing factors, and interventions. METHODS: A focused review was performed of all articles in English that address the topic from 1980 to 2018. RESULTS: Innate patient factors, rather than intraoperative factors, affect the development of neurodevelopmental outcomes, yet a large portion of causality factors remains unexplained. There are also limits to how we currently measure neurodevelopmental outcomes. Limited studies in adulthood and a lack of longitu..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) Partnership grant (1076849). Prof Yves d'Udekem is a Clinician Practitioner Fellow of the NHMRC (1082186). The authors wish to thank the participants of the study and their research assistants for their support in maintaining the Australian and New Zealand Fontan Registry and also acknowledge the support provided to the Murdoch Children's Research Institute by the Victorian Government's Operational Infrastructure Support Program.