Journal article
Early osmotherapy in severe traumatic brain injury: An international multicenter study
JR Anstey, FS Taccone, AA Udy, G Citerio, J Duranteau, C Ichai, R Badenes, JR Prowle, A Ercole, M Oddo, AG Schneider, M Van Der Jagt, S Wolf, R Helbok, DW Nelson, MB Skrifvars, A Harrois, J Presneill, DJ Cooper, M Bailey Show all
Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2020
Abstract
The optimal osmotic agent to treat intracranial hypertension in patients with severe traumatic brain injury (TBI) remains uncertain. We aimed to test whether the choice of mannitol or hypertonic saline (HTS) as early (first 96 h) osmotherapy in these patients might be associated with a difference in mortality. We retrospectively analyzed data from 2015 from 14 tertiary intensive care units (ICUs) in Australia, UK, and Europe treating severe TBI patients with intracranial pressure (ICP) monitoring and compared mortality in those who received mannitol only versus HTS only. We performed multi-variable analysis adjusting for site and illness severity (Injury Severity Score, extended IMPACT score..
View full abstract