Journal article

Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study

James R Anstey, Fabio S Taccone, Andrew A Udy, Giuseppe Citerio, Jacques Duranteau, Carole Ichai, Rafael Badenes, John R Prowle, Ari Ercole, Mauro Oddo, Antoine G Schneider, Mathieu van der Jagt, Stefan Wolf, Raimund Helbok, David W Nelson, Marius B Skrifvars, Anatole Harrois, Jeffrey Presneill, D Jamie Cooper, Michael Bailey Show all

Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2019


The optimal osmotic agent to treat intracranial hypertension in patients with severe traumatic brain injury (TBI) remains uncertain. We aimed to test whether the choice of mannitol or hypertonic saline (HTS) as early (first 96 hours) osmotherapy in these patients might be associated with a difference in mortality. We retrospectively analysed data from 2015 from 14 tertiary ICUs in Australia, UK and Europe treating severe TBI patients with intracranial pressure (ICP) monitoring, and compared mortality in those who received mannitol only versus HTS only. We performed multivariable analysis adjusting for site and illness severity (Injury Severity Score, extended IMPACT score, and mean intracran..

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