Journal article

Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial

Vijay K Venkatraman, Andrew Sanderson, Kay L Cox, Kathryn A Ellis, Christopher Steward, Pramit M Phal, Alexandra Gorelik, Matthew J Sharman, Victor L Villemagne, Michelle Lai, Elizabeth Cyarto, Bernd Merkel, David Ames, Cassandra Szoeke, Christopher C Rowe, Colin L Masters, Nicola T Lautenschlager, Patricia M Desmond



White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or th..

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Awarded by Australia's National Health and Medical Research Council

Funding Acknowledgements

Australia's National Health and Medical Research Council; Contract grant number: 1005492. Funding for the AIBL study is provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), Mental Health Research institute (MHRI), Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd, Hollywood Private Hospital, and Sir Charles Gardner Hospital. The study also received funding from the National Health and Medical Research Council, the Dementia Collaborative Research Centres program (DCRC2) and The McCusker Alzheimer's Research Foundation and Operational Infrastructure Support from the Government of Victoria.