Conference Proceedings
Meta-Analysis of Hippocampal Subfields: Results From the ENIGMA-MDD Working Group
Philipp Saemann, Michael Czisch, Neda Jahanshad, Christopher D Whelan, Laura van Velzen, Derrek Hibar, Laura Han, Ilya M Veer, Henrik Walter, Dick Veltman, Lianne Schmaal
BIOLOGICAL PSYCHIATRY | ELSEVIER SCIENCE INC | Published : 2019
Abstract
Background Hippocampal volume reductions in major depressive disorder (MDD) represent a robust finding in retrospective meta-analyses. Subregional specificity of this finding has been suspected from several smaller previous studies. Given the complex role of the hippocampus both for stress response regulation and its vulnerability to chronic disease, we aim at finer mapping of this result using FreeSurfer based, automated subfield segmentation. Methods Twenty-three centers with MDD/control samples contributed. Results reported here stem from 2522 patients and 4244 controls. After segmentation and standardized QC, local statistical were run for 25 models in total. Key models were: Cases vs..
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