Journal article

Early-life determinants of hypoxia-inducible factor 3A gene(HIF3A) methylation: a birth cohort study

Toby Mansell, Anne-Louise Ponsonby, Vania Januar, Boris Novakovic, Fiona Collier, David Burgner, Peter Vuillermin, Joanne Ryan, Richard Saffery, John Carlin, Katie Allen, Mimi Tang, Sarath Ranganathan, Terry Dwyer, Kim Jachno, Peter Sly



BACKGROUND: Methylation of the hypoxia-inducible factor 3α gene (HIF3A) has been linked to pregnancy exposures, infant adiposity and later BMI. Genetic variation influences HIF3A methylation levels and may modify these relationships. However, data in very early life are limited, particularly in association with adverse pregnancy outcomes. We investigated the relationship between maternal and gestational factors, infant anthropometry, genetic variation and HIF3A DNA methylation in the Barwon Infant Study, a population-based birth cohort. Methylation of two previously studied regions of HIF3A were tested in the cord blood mononuclear cells of 938 infants. RESULTS: No compelling evidence was fo..

View full abstract


Awarded by NHMRC

Awarded by NHMRC Dementia Research Leader Fellowship

Funding Acknowledgements

The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited and the Percy Baxter Charitable Trust, Perpetual Trustees. In-kind support was provided by the Cotton On Foundation and CreativeForce. The study sponsors were not involved in the collection, analysis and interpretation of data; writing of the report; or the decision to submit the report for publication. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. This work was also supported by a Research Training Program Stipend through University of Melbourne (to TM), NHMRC Senior Research Fellowships (APP1008396 to ALP; APP1045161 to RS); and an NHMRC Dementia Research Leader Fellowship (APP1135727 to JR).