Dosing pole recommendations for lymphatic filariasis elimination: A height-weight quantile regression modeling approach
Charles W Goss, Katiuscia O'Brian, Christine Dubray, Peter U Fischer, Myra Hardy, Purushothaman Jambulingam, Christopher L King, Moses Laman, Jean Frantz Lemoine, Leanne J Robinson, Josaia Samuela, Swaminathan Subramanian, Taniawati Supali, Gary J Weil, Kenneth B Schechtman
PLOS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2019
BACKGROUND: The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs. The goals of our study were to compare these alternative dosing strategies to weight-based dosing and to develop and evaluate new height-based dosing pole scenarios. METHODOLOGY/PRINCIPAL FINDINGS: Age, height and weight data were collected from >26,000 individuals in five countries during a cluster randomized LF clinical trial. Weight-based dosing for diethylcarbamazine (DEC; 6 mg/kg) and ivermectin (IVM; 200 ug/kg) with tablet numbers derived from a table of weight intervals was tr..View full abstract
This project was funded by the Bill & Melinda Gates Foundation (https://www.gatesfoundation.org/) and by the Coalition for Operational Research on Neglected Tropical Diseases (https://www.ntdsupport.org/cor-ntd) that is funded by the Gates Foundation, USAID, and DFID (UK). Author Gary J. Weil is the PI of the project, and work by all of the authors who participated in the project was funded by these funding agencies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.