Journal article

Computerized Cognitive Training in Multiple Sclerosis: A Systematic Review and Meta-analysis

Amit Lampit, Josephine Heine, Carsten Finke, Michael H Barnett, Michael Valenzuela, Anna Wolf, Isabella HK Leung, Nicole TM Hill



Background. Cognitive impairments are common in people with multiple sclerosis (MS). Systematic reviews reported promising evidence for various cognitive interventions in this population. Computerized cognitive training (CCT) has strong evidence for safety and efficacy in several populations, but its effects in MS have yet to be specified. Objective. We aimed to synthesize the evidence from randomized controlled trials (RCTs) investigating the effects of CCT on cognitive, psychosocial, and functional outcomes in adults with MS. Method. We searched MEDLINE, EMBASE, PsycINFO, CINAHL, and CENTRAL from inception to March 2019. We calculated standardized mean difference (Hedges' g) of change from..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by HHMRC scholarship

Awarded by German Federal Ministry of Education and Research (BMBF)

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: AL and MV are funded by research fellowships from the National Health and Medical Research Council of Australia (NHMRC Grant IDs 1108520 and 1112813). IHKL was funded by a HHMRC scholarship (ID 1133682). NTMH is funded by Australian Rotary Health scholarship. CF and MV receive research support in the form of cognitive training software free of charge from Synaptikon (Berlin) for projects unrelated to this work. CF is a lead investigator and AL is partially funded by a grant from German Federal Ministry of Education and Research (BMBF, ID 13GW0212A) to develop a cognitive assessment and intervention platform in collaboration with Synaptikon.