Associations Between Bone Impact Microindentation and Clinical Risk Factors for Fracture
Pamela Rufus-Membere, Kara L Holloway-Kew, Adolfo Diez-Perez, Mark A Kotowicz, Julie A Pasco
Endocrinology | ENDOCRINE SOC | Published : 2019
Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, clinical risk factors that affect BMSi are largely unknown. This study investigated associations between BMSi and clinical risk factors for fracture in men. BMSi was measured using the OsteoProbe in 357 men (ages 33 to 96 years) from the Geelong Osteoporosis Study. Risk factors included age, weight, height, body mass index (BMI), femoral neck bone mineral density (BMD), parental hip fracture, prior fracture, type 2 diabetes mellitus (T2DM), secondary osteoporosis, smoking, alcohol consumption, sedentary lifestyle, medications, diseases, and low serum vitamin D levels. BMSi was negatively associated w..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
The Geelong Osteoporosis Study was supported by grants from the National Health and Medical Research Council (NHMRC; projects 299831 and 628582, to J.A.P.) and Amgen-GSK OA-ANZBMS (to J.A.P.), but these supporters played no role in the collection or interpretation of data. P.R.-M. is supported by a Deakin University Postgraduate Industry Research Scholarship. K.L.H.-K. is supported by an Alfred Deakin Postdoctoral Research Fellowship. A.D.-P. owns shares of Active Life Scientific, Inc., the manufacturer of the RPI device. M.A.K. and J.A.P. are recipients of grants from the NHMRC and Amgen-GSK OA-ANZBMS.