Cerebral Blood Flow in Community-Based Older Twins Is Moderately Heritable: An Arterial Spin Labeling Perfusion Imaging Study
Jiyang Jiang, Anbupalam Thalamuthu, Forrest C Koch, Tao Liu, Qun Xu, Julian N Trollor, David Ames, Margaret J Wright, Vibeke Catts, Perminder S Sachdev, Wei Wen
Frontiers in Aging Neuroscience | FRONTIERS MEDIA SA | Published : 2019
Adequate cerebral blood flow (CBF) is necessary to maintain brain metabolism and function. Arterial spin labeling (ASL) is an emerging MRI technique offering a non-invasive and reliable quantification of CBF. The genetic basis of CBF has not been well documented, and one approach to investigate this is to examine its heritability. The current study aimed to examine the heritability of CBF using ASL data from a cohort of community-dwelling older twins (41 monozygotic (MZ) and 25 dizygotic (DZ) twin pairs; age range, 65-93 years; 56.4% female). The results showed that the cortex had higher CBF than subcortical gray matter (GM) regions, and CBF in the GM regions of the anterior cerebral artery ..View full abstract
JJ is a John Holden Family Foundation Postdoctoral Research Fellow. This study was undertaken with the assistance of resources and services from the National Computational Infrastructure (NCI), which is supported by the Australian Government.