Journal article

Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history

Mark Jenkins, Aung Win, James Dowty, Robert MacInnis, Enes Makalic, Daniel Schmidt, Gillian Dite, Miroslaw Kapuscinski, Mark Clendenning, Christophe Rosty, Ingrid Winship, Jon Emery, Sibel Saya, Finlay Macrae, Dennis Ahnen, David Duggan, Jane Figueiredo, Noralane Lindor, Robert Haile, John Potter Show all

Published : 2018

Abstract

ABSTRACT Background A number of single nucleotide polymorphisms (SNPs), which are common inherited genetic variants, have been identified that are associated with risk of colorectal cancer. The aim of this study was to determine the ability of these SNPs to estimate colorectal cancer (CRC) risk for persons with and without a family history of CRC, and the screening implications. Methods We estimated the association with CRC of a 45 SNP-based risk using 1,181 cases and 999 controls, and its correlation ( r ) with CRC risk predicted from detailed family history. We estimated the predicted change in the distribution across predefined risk categories, and implications for recommended age to comm..

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