Journal article

Cortical remodelling in childhood is associated with genes enriched for neurodevelopmental disorders

G Ball, J Seidlitz, R Beare, ML Seal

Published : 2019


Cortical development during childhood and adolescence has been characterised in recent years using metrics derived from Magnetic Resonance Imaging (MRI). Changes in cortical thickness are greatest in the first two decades of life and recapitulate the genetic organisation of the cortex, highlighting the potential early impact of gene expression on differences in cortical architecture over the lifespan. It is important to further our understanding of the possible neurobiological mechanisms that underlie these changes as differences in cortical thickness may act as a potential phenotypic marker of several common neurodevelopmental and psychiatric disorders. In this study, we combine MRI acquire..

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