Journal article
Association of Medication Intensity and Stages of Airflow Limitation with the Risk of Hospitalization or Death in Patients with Heart Failure and Chronic Obstructive Pulmonary Disease
CA Lawson, MA Mamas, PW Jones, L Teece, G McCann, K Khunti, UT Kadam
JAMA Network Open | AMER MEDICAL ASSOC | Published : 2018
Abstract
Importance: In heart failure (HF), chronic obstructive pulmonary disease (COPD) increases the risk of poor outcomes, but the effect of COPD severity is unknown. This information is important for early intervention tailored to the highest-risk groups. Objectives: To determine the associations between COPD medication intensity or stage of airflow limitation and the risk of hospitalization or death in patients with HF. Design, Setting, and Participants: This UK population-based, nested case-control study with risk-set sampling used the Clinical Practice Research Datalink linked to Hospital Episode Statistics between January 1, 2002, to January 1, 2014. Participants included patients aged 40 yea..
View full abstractGrants
Awarded by National Institute for Health Research (NIHR)
Awarded by Leicester-Wellcome Trust
Funding Acknowledgements
The study was supported by grant NIHR-DRF-2012-05-288 from the National Institute for Health Research (NIHR) doctoral fellowship; the NIHR Collaboration for Leadership in Applied Health Research and Care-East Midlands; the NIHR Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Centre, which is a partnership between University Hospitals of Leicester National Health Service Trust, Loughborough University, and the University of Leicester; and award 204801/Z/16/Z from Leicester-Wellcome Trust Institutional Strategic Support Fund Fellowship.