Association of Medication Intensity and Stages of Airflow Limitation With the Risk of Hospitalization or Death in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease.
Claire A Lawson, Mamas A Mamas, Peter W Jones, Lucy Teece, Gerry McCann, Kamlesh Khunti, Umesh T Kadam
JAMA Netw Open | Published : 2018
Importance: In heart failure (HF), chronic obstructive pulmonary disease (COPD) increases the risk of poor outcomes, but the effect of COPD severity is unknown. This information is important for early intervention tailored to the highest-risk groups. Objectives: To determine the associations between COPD medication intensity or stage of airflow limitation and the risk of hospitalization or death in patients with HF. Design, Setting, and Participants: This UK population-based, nested case-control study with risk-set sampling used the Clinical Practice Research Datalink linked to Hospital Episode Statistics between January 1, 2002, to January 1, 2014. Participants included patients aged 40 yea..View full abstract
Awarded by Department of Health
Awarded by Wellcome Trust