Journal article

Is (poly-) substance Use associated with impaired inhibitory control? A fmega-analysis controlling for confounders

Yang Liu, Wery PM van den Wildenberg, Ysanne de Graaf, Susan L Ames, Alexander Baldacchino, Ragnhild Bo, Fernando Cadaveira, Salvatore Campanella, Paul Christiansen, Eric D Claus, Lorenza S Colzato, Francesca M Filbey, John J Foxe, Hugh Garavan, Christian S Hendershot, Robert Hester, Jennifer M Jeste, Hollis C Karoly, Anja Kraeplin, Fanny Kreusch Show all

Neuroscience & Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019


Many studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly "recreational" substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics ..

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Awarded by China scholarship council (CSC)

Awarded by Netherlands Organization of Scientific Research (NWO)

Funding Acknowledgements

China scholarship council (CSC) (No. 201506990019).VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005].