Engineering the Interface: Nanodiamond Coating on 3D-Printed Titanium Promotes Mammalian Cell Growth and Inhibits Staphylococcus aureus Colonization
Aaqil Rifai, Nhiem Tran, Philipp Reineck, Aaron Elbourne, Edwin Mayes, Avik Sarker, Chaitali Dekiwadia, Elena P Ivanova, Russell J Crawford, Takeshi Ohshima, Brant C Gibson, Andrew D Greentree, Elena Pirogova, Kate Fox
ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2019
Additively manufactured selective laser melted titanium (SLM-Ti) opens the possibility of tailored medical implants for patients. Despite orthopedic implant advancements, significant problems remain with regard to suboptimal osseointegration at the interface between the implant and the surrounding tissue. Here, we show that applying a nanodiamond (ND) coating onto SLM-Ti scaffolds provides an improved surface for mammalian cell growth while inhibiting colonization of Staphylococcus aureus bacteria. Owing to the simplicity of our methodology, the approach is suitable for coating SLM-Ti geometries. The ND coating achieved 32 and 29% increases in cell density of human dermal fibroblasts and ost..View full abstract
Awarded by Australian Research Council (ARC)
K.F. is supported by the Clive and Vera Ramaciotti Foundation and the CASS Foundation (Medicine and Science). K.F. also acknowledges the Australian Research Council (ARC) for funding (IC160100026). B.C.G. and A.D.G. acknowledge the Australian Research Council (ARC) for the funding (CE140100003 and FT160100357).