The Limitations of the Rheumatogenic Concept for Group A Streptococcus: Systematic Review and Genetic Analysis
Gabrielle de Crombrugghe, Noemie Baroux, Anne Botteaux, Nikki J Moreland, Deborah A Williamson, Andrew C Steer, Pierre R Smeesters
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020
BACKGROUND: The concept that a minority of group A streptococcus (GAS) emm types are more "rheumatogenic" than others has been widely disseminated. We aimed to provide a comprehensive list of acute rheumatic fever-associated GAS isolates and assess the presence of associated rheumatogenic motifs. METHODS: Articles reporting GAS emm-type or emm-type-specific antibody responses associated with rheumatic fever were identified from 1 January 1944 to 31 July 2018. The revised Jones criteria were used to define rheumatic fever with a maximum period of 4 weeks between disease onset and microbiological characterization. A database of 175 representative M-protein sequences was used to analyze the pro..View full abstract
Awarded by Belgian Fonds National de la Recherche Scientifique
This work was supported by the Belgian Fonds National de la Recherche Scientifique (grant number FNRS PDR N degrees T.0255.16F).