Journal article

The Limitations of the Rheumatogenic Concept for Group A Streptococcus: Systematic Review and Genetic Analysis

Gabrielle de Crombrugghe, Noemie Baroux, Anne Botteaux, Nikki J Moreland, Deborah A Williamson, Andrew C Steer, Pierre R Smeesters

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020


BACKGROUND: The concept that a minority of group A streptococcus (GAS) emm types are more "rheumatogenic" than others has been widely disseminated. We aimed to provide a comprehensive list of acute rheumatic fever-associated GAS isolates and assess the presence of associated rheumatogenic motifs. METHODS: Articles reporting GAS emm-type or emm-type-specific antibody responses associated with rheumatic fever were identified from 1 January 1944 to 31 July 2018. The revised Jones criteria were used to define rheumatic fever with a maximum period of 4 weeks between disease onset and microbiological characterization. A database of 175 representative M-protein sequences was used to analyze the pro..

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Awarded by Belgian Fonds National de la Recherche Scientifique

Funding Acknowledgements

This work was supported by the Belgian Fonds National de la Recherche Scientifique (grant number FNRS PDR N degrees T.0255.16F).