Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms
Cristina Renzi, Aradhna Kaushal, Jon Emery, Willie Hamilton, Richard D Neal, Bernard Rachet, Greg Rubin, Hardeep Singh, Fiona M Walter, Niek J de Wit, Georgios Lyratzopoulos
NATURE REVIEWS CLINICAL ONCOLOGY | NATURE PUBLISHING GROUP | Published : 2019
An earlier diagnosis is a key strategy for improving the outcomes of patients with cancer. However, achieving this goal can be challenging, particularly for the growing number of people with one or more chronic conditions (comorbidity/multimorbidity) at the time of diagnosis. Pre-existing chronic diseases might affect patient participation in cancer screening, help-seeking for new and/or changing symptoms and clinicians' decision-making on the use of diagnostic investigations. Evidence suggests, for example, that pre-existing pulmonary, cardiovascular, neurological and psychiatric conditions are all associated with a more advanced stage of cancer at diagnosis. By contrast, hypertension and c..View full abstract
Awarded by Cancer Research UK
Awarded by VA Health Services Research and Development Service Center for Innovations in Quality, Effectiveness and Safety
This research arises from the CanTest Collaborative, which is funded by Cancer Research UK (C8640/A23385). C.R. acknowledges funding from a BMA TP Gunton research grant. H.S. is partly supported by the VA Health Services Research and Development Service Center for Innovations in Quality, Effectiveness and Safety (CIN13-413). G.L. acknowledges funding from Cancer Research UK (Advanced Clinician Scientist Fellowship Award, grant number C18081/A18180). J.E. acknowledges funding from an NHMRC Practitioner Fellowship.