Journal article
RPW8/HR repeats control NLR activation in Arabidopsis thaliana
CA Barragan, R Wu, ST Kim, W Xi, A Habring, J Hagmann, AL Van de Weyer, M Zaidem, WWH Ho, G Wang, I Bezrukov, D Weigel, E Chae
Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2019
Abstract
In many plant species, conflicts between divergent elements of the immune system, especially nucleotide-binding oligomerization domain-like receptors (NLR), can lead to hybrid necrosis. Here, we report deleterious allele-specific interactions between an NLR and a non-NLR gene cluster, resulting in not one, but multiple hybrid necrosis cases in Arabidopsis thaliana. The NLR cluster is RESISTANCE TO PERONOSPORA PARASITICA 7 (RPP7), which can confer strain-specific resistance to oomycetes. The non-NLR cluster is RESISTANCE TO POWDERY MILDEW 8 (RPW8)/HOMOLOG OF RPW8 (HR), which can confer broad-spectrum resistance to both fungi and oomycetes. RPW8/HR proteins contain at the N-terminus a potentia..
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Awarded by Max-Planck-Gesellschaft
Funding Acknowledgements
This study was supported by a Marie Curie postdoctoral fellowship (2014-655295, https://ec.europa.eu/research/mariecurieactions/actions/individual-fellowships_en) to RW, the Academic Research Fund from the National University of Singapore (R-154-000-B33-114, https://www.nrf.gov.sg/) to EC, ERC Advanced Grant IMMUNEMESIS (340602, https://erc.europa.eu/funding/advanced-grants), the Deutsche Forschungsgemeinschaft through the Collaborative Research Center (CRC1101, https://www.dfg.de/en/research_funding/programmes/coordinated_programmes/collaborative_research_centres/), and The Max Planck Society (https://www.mpg.de/en) to DW. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.