Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock
Eduardo Atsushi Osawa, Salvatore Lucio Cutuli, Laurent Bitker, Emmanuel Canet, Luca Cioccari, Naoya Iguchi, Yugeesh R Lankadeva, Glenn M Eastwood, Roger G Evans, Clive N May, Rinaldo Bellomo
Blood Purification | KARGER | Published : 2019
BACKGROUND: Renal medullary hypoxia precedes the development of acute kidney injury in experimental sepsis and can now be assessed by continuous measurement of urinary oxygen tension (PuO2). OBJECTIVES: We aimed to test if PuO2 measurements in patients with septic shock would be similar to those shown in experimental sepsis and would detect changes induced by the administration of furosemide. METHOD: Pilot prospective observational cohort study in a tertiary intensive care unit (ICU). Seven adult patients with septic shock admitted to ICU had PuO2 measurements recorded minutely. There were 29 episodes of intravenous furosemide (20 mg n = 19; 40 mg n = 10). RESULTS: The median pre-furosemide ..View full abstract
A financial support for this study was received from Anaesthesia and Intensive Care Trust Fund, Austin Hospital. The funding source had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the article for publication.