Journal article

Goal directed fluid therapy for major liver resection: A multicentre randomized controlled trial

Laurence Weinberg, Damian Ianno, Leonid Churilov, Steven Mcguigan, Lois Mackley, Jonathan Banting, Shi Hong Shen, Bernhard Riedel, Mehrdad Nikfarjam, Chris Christophi

Annals of Medicine and Surgery | ELSEVIER SCI LTD | Published : 2019


Background: The effect a restrictive goal directed therapy (GDT) fluid protocol combined with an enhanced recovery after surgery (ERAS) programme on hospital stay for patients undergoing major liver resection is unknown. Methods: We conducted a multicentre randomized controlled pilot trial evaluating whether a patient-specific, surgery-specific intraoperative restrictive fluid optimization algorithm would improve duration of hospital stay and reduce perioperative fluid related complications. Results: Forty-eight participants were enrolled. The median (IQR) length of hospital stay was 7.0 days (7.0:8.0) days in the restrictive fluid optimization algorithm group (Restrict group) vs. 8.0 days (..

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