Journal article

Female fertility preservation in DSD

Rashi Kalra, Melissa Cameron, Catharyn Stern

Best Practice & Research Clinical Endocrinology & Metabolism | ELSEVIER SCI LTD | Published : 2019

Abstract

Disorders of sex development (DSD) are a group of complex conditions that can affect chromosomal, gonadal, and/or phenotypical sex with a highly variable fertility potential amongst affected individuals. In this review we discuss fertility issues facing patients affected by DSD and Turner syndrome and summarise the literature on fertility and reproductive outcomes. We will also discuss fertility preservation prior to gonadotoxic treatment in adolescent and prepubertal girls. Future directions in fertility preservation and ethical issues will also be addressed. Fertility preserving options that are established include ovarian tissue and oocyte cryopreservation. However, in many of the DSDs fe..

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