Journal article

Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study

Fiona A Wilkes, Zvart Abaryan, Chris RK Ching, Boris A Gutman, Sarah K Madsen, Mark Walterfang, Dennis Velakoulis, Julie C Stout, Phyllis Chua, Gary F Egang, Paul M Thompson, Jeffrey CL Looi, Nellie Georgiou-Karistianisg

Psychiatry Research: Neuroimaging | ELSEVIER IRELAND LTD | Published : 2019

Abstract

We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping protocol derived two pointwise shape measures: thickness and surface dilation ratio. Significant shape differences were detected between all groups. Negative associations were detected between lower thickness and surface area shape measure and CAG repeats, disease burden score, and UHDRS total motor..

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Grants

Awarded by CHDI Foundation, Inc. (USA)


Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This work was supported by the CHDI Foundation, Inc. (USA) (grant number A - 3433); the National Health and Medical Research Council (NHMRC) (grant number 606650); the RANZCP New Investigator grant 2013 (FAW); and the University of Melbourne - computer and software support