Journal article

The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in multiple sclerosis

Daniel Merlo, David Darby, Tomas Kalincik, Helmut Butzkueven, Anneke van der Walt

Therapeutic Advances in Neurological Disorders | SAGE PUBLICATIONS LTD | Published : 2019


Background: Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent retesting. Brief, reliable and valid monitoring tools are urgently needed to detect subtle, subclinical cognitive changes in people with MS. Cognitive monitoring over time could contribute to a new definition of disease progression, supplementing routine clinical monitoring. Methods: MSReactor is a web-based battery that measures psychomotor (processing) speed, visual attention and working memory, using simple reaction time tasks. Clinic-based tasks were completed at baseline and 6 monthly with home testing 1-3 monthly. Acceptability, quality of life, depression an..

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Awarded by Novartis Australia

Funding Acknowledgements

The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: this work was supported by the Novartis Australia (grant number CFTY720DAU08T).