Journal article

No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

Carolien GF de Kovel, Lyubomir Aftanas, Andre Aleman, Aaron F Alexander-Bloch, Bernhard T Baune, Ivan Brack, Robin Bulow, Geraldo Busatto Filho, Angela Carballedo, Colm G Connolly, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Danai Dima, Katharina Dohm, Tracy Erwin-Grabner, Thomas Frodl, Cynthia HY Fu, Geoffrey B Hall, David C Glahn Show all

American Journal of Psychiatry | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2019

Abstract

OBJECTIVE: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from d..

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