Journal article

Genetic Analysis of Patients Who Experienced Awareness with Recall while under General Anesthesia

Jamie W Sleigh, Kate Leslie, Andrew J Davidson, David J Amor, Peter Diakumis, Vesna Lukic, Paul J Lockhart, Melanie Bahlo

Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

BACKGROUND: Intraoperative awareness with recall while under apparently adequate general anesthesia is a rare, unexplained, and often very distressing phenomenon. It is possible that a relatively small number of genetic variants might underlie the failure of general anesthetic drugs to adequately suppress explicit memory formation and recall in the presence of apparently adequate anesthesia concentrations. METHODS: The authors recruited 12 adult patients who had experienced an episode of intraoperative awareness with recall (compared with 12 controls), performed whole exome sequencing, and applied filtering to obtain a set of genetic variants that might be associated with intraoperative awar..

View full abstract

Grants

Awarded by Australian and New Zealand College of Anaesthetists


Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship


Awarded by NHMRC Senior Research Fellowship


Awarded by NHMRC program grant


Funding Acknowledgements

This study was funded by the project grant from the Australian and New Zealand College of Anaesthetists (Application ID: 11/006). Dr. Lockhart was supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship (GNT1032364). Dr. Bahlo was supported by an NHMRC Senior Research Fellowship (GNT1102971) and NHMRC program grant (GNT1054618). This work was also supported by Victorian State Government Operational Infrastructure Support.