Journal article

Anatomical imaging of the piriform cortex in epilepsy

James C Young, David N Vaughan, Helen M Nasser, Graeme D Jackson

Experimental Neurology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019


The piriform cortex is a distinct brain region that plays a key role in the sense of smell. The piriform cortex is the major part of primary olfactory cortex and has broad connections that extend beyond the olfactory regions into limbic and fronto-temporal cortical networks. Numerous studies have described these anatomical connections via microscopic imaging and tracer studies. More recently, macroscopic anatomical imaging studies have demonstrated changes in the piriform cortex in humans with focal epilepsy as well as in animal models, suggesting this brain region can play a critical role in epileptogenesis. This review examines the imaging methods and techniques that have been most informa..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. This study was supported by the National Health and Medical Research Council of Australia (NHMRC Project Grant 1091593). James C Young acknowledges that they have been supported through an Australian Government Research Training Program Scholarship.