Journal article

Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections

N Komadina, SG Sullivan, K Kedzierska, SM Quinones-Parra, K Leder, J McVernon

Epidemiology and Infection | CAMBRIDGE UNIV PRESS | Published : 2019


The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health. K. Kedzierska is supported by The Australian National Health and Medical Research Council (NHMRC), NHMRC Program Grant (1071916), and is a NHMRC Senior Research Level B Fellow. J. McVernon is a NHMRC Principal Research Fellow (1117140).