The Effect of Maternal Immunisation During Pregnancy on Infant Vaccine Responses
Petra Zimmermann, Kirsten P Perrett, Nicole L Messina, Susan Donath, Nicole Ritz, Fiona RM van der Klis, Nigel Curtis
ECLINICALMEDICINE | ELSEVIER | Published : 2019
Introduction: Immunisation during pregnancy to protect infants against tetanus, pertussis and influenza is recommended in many countries. However, maternal antibodies can interfere with infant vaccine responses. We investigated the effect of antenatal diphtheria-tetanus-acellular pertussis (dTpa) and trivalent inactivated influenza (TIV) immunisation on specific and heterologous antibody responses to routine immunisations given in the first year of life. Methods: In total, 471 healthy infants were included. At 7 and 13 months of age, antibodies to the primary course of routine vaccines given at 6 weeks, 4 and 6 months of age (pertussis (pertussis toxin (PT), filamentous haemagglutinin (FHA),..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
This work was supported by the Australian National Health and Medical Research Council (NHMRC) (grants GNT1051228 and GNT1099680), The University of Melbourne (International Research Scholarship to PZ), and the European Society for Paediatric Infectious Disease (ESPID) (Fellowship to PZ). KP is supported by a Melbourne Children's ClinicianScientist Fellowship. We thank Ms. Susie Germano and Ms. Rhian Bonnici for their helpwith data entry and the processing of blood samples, aswell as Ms. Kaya Gardiner for project co-ordination. We also thank Prof Andrew Pollard for his helpful comments on the manuscript.