Novel Vitronectin Variations and Their Comparative Analysis in Six Porcine Breeds
Wei Yan, Xutin Zhao, Juyin Li, Long Cheng, Yanqing Li
Animals | MDPI | Published : 2019
Vitronectin plays a role in the blood homeostasis and has been implicated in cell adhesion, migration, and proliferation. Vitronectin has a potential role affecting the residual feed intake (RFI) or feeding efficiency in swine production. Its variations have not been reported in Chinese swine breeds. In this study, two regions of porcine vitronectin were analyzed using PCR and sequencing. The sequence analysis revealed thirteen nucleotide substitutions in region 1 (exon 2- exon 3) and three nucleotide substitutions in region 2 (exon 5- intron 5), which would result in five amino acid changes (p.Ala52Thr, p.Leu94Pro, p.Leu94Gln, p.Gln94Pro, and p.Glu126Gly). In region 1, c.156C/T, c.281A/T, a..View full abstract
Awarded by program of capacity building and industrialization of biological breeding from the National Development and Reform Commission
This research was funded by the program of capacity building and industrialization of biological breeding from the National Development and Reform Commission, grant number 2150299.