Journal article

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice.

Agnes E Coutinho, Tiina MJ Kipari, Zhenguang Zhang, Cristina L Esteves, Christopher D Lucas, James S Gilmour, Scott P Webster, Brian R Walker, Jeremy Hughes, John S Savill, Jonathan R Seckl, Adriano G Rossi, Karen E Chapman

Endocrinology | Published : 2016

Abstract

Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respectively. 11β-HSD1 is highly expressed in immune cells elicited to the mouse peritoneum during thioglycollate-induced peritonitis and is down-regulated as the inflammation resolves. During inflammation, 11β-HSD1-deficient mice show enhanced recruitment of inflammatory cells and delayed acquisition of macrophage phagocytic capacity. However, the key cells in which 11β-HSD1 exerts these effects remain unknown. Here we have identified neutro..

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