Journal article
11β-hydroxysteroid dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice
AE Coutinho, TMJ Kipari, Z Zhang, CL Esteves, CD Lucas, JS Gilmour, SP Webster, BR Walker, J Hughes, JS Savill, JR Seckl, AG Rossi, KE Chapman
Endocrinology | ENDOCRINE SOC | Published : 2016
DOI: 10.1210/en.2016-1118
Abstract
Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respectively. 11β-HSD1 is highly expressed in immune cells elicited to the mouse peritoneum during thioglycollate-induced peritonitis and is down-regulated as the inflammation resolves. During inflammation, 11β-HSD1-deficient mice show enhanced recruitment of inflammatory cells and delayed acquisition of macrophage phagocytic capacity. However, the key cells in which 11β-HSD1 exerts these effects remain unknown. Here we have identified neutr..
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Awarded by UK Research and Innovation
Funding Acknowledgements
This work was supported by Medical Research Council Project Grant G0800235 and by Wellcome Trust Programme Grants 083184 and 064497 and Wellcome Trust Seeding Drug Discovery Award 078269. This work was also supported by Wellcome Trust Grant WT094415 (to C.D.L.) and the UK Medical Research Council Grants G0601481 and MR/K013386/1 (to A.G.R.).