GLOMERULAR MESANGIAL CELLS AND INFLAMMATORY MACROPHAGES INGEST NEUTROPHILS UNDERGOING APOPTOSIS

Abstract

Apoptosis or programmed cell death of senescent neutrophils leading to their uptake by phagocytes is a general mechanism by which neutrophils may be removed from inflamed sites in vivo, promoting resolution rather than persistence of inflammation. We now report morphological evidence of neutrophil apoptosis leading to uptake by glomerular cells in rats with experimental glomerulonephritis. In addition to confirming that inflammatory macrophages take up apoptotic neutrophils, these studies indicated that glomerular mesangial cells can also participate in this mode of neutrophil clearance. Furthermore, human neutrophils which had been "aged" in vitro so as to undergo apoptosis were ingested by..